Chemistry (CHEM)

Description: Chemical and physical properties applied to quantitative chemical analysis. Solution equilibria, stoichiometry, and instrumental theory and techniques.

Description: Lab designed to accompany CHEM 421/821. Applications of analytical chemical principles to laboratory problems.

Description: Selection and execution of analytical methods in the solution of typical academic and industrial chemical problems.

Description: Survey of theory of ionic equilibrium systems of importance in chemical analysis.

Description: Survey of principles and applications of electroanalytical chemistry.

Description: Comprehensive study of the fundamentals and applications of mass spectrometry including ionization methods, mass analyzers, hybrid instruments, and ion dissociation methods. Each topic will include illustrative examples involving a variety of analytes and application areas.

Description: Application of statistical, graphical and numerical methods for the treatment of analytical chemical data.

Description: Survey of principles and applications of modern chromatographic analysis including the general chemical and physical principles of chemical separations, gas or liquid chromatography, and electrophoretic methods. The applications and instrumentation in these methods are discussed, along with advanced separation techniques and hybrid methods.

Description: Survey of principles and analytical application of modern optical spectrometric methods.

Description: Introduction to the theory and techniques of nuclear magnetic resonance (NMR) spectroscopy with a particular application to the structure determination of organic compounds. Basic theory of NMR that includes chemical shifts, coupling constants and relaxation. Topics include the application and analysis of two-dimensional NMR spectra to determine chemical structures, the basic design and implementation of an NMR experiment or pulse sequence, and NMR instrumentations, RF pulses, experimental and processing parameters.

Description: Structure and function of proteins, nucleic acids, carbohydrates and lipids; nature of enzymes; major metabolic pathways of catabolism; and biochemical energy production.

Description: Major metabolic pathways of anabolism, structural and biochemical aspects of biological information flow and use in biotechnology.

Description: Introduction to techniques used in biochemical and biotechnology research, including measurement of pH, spectroscopy, analysis of enzymes, chromatography, fractionation of macromolecules, electrophoresis, and centrifugation.

Description: Biochemical metabolism unique to plants. Relationships of topics previously acquired in general biochemistry to biochemical processes unique to plants. Biochemical mechanisms behind physiological processes discussed in plant or crop physiology.

Description: Fundamentals of chemical biology with an emphasis on the underlying principles of biomolecular structures, macromolecular-small molecule interactions, including mechanistic aspects of enzymes and cofactors, use of modified enzymes to alter biochemical pathways, and the use of chemical tools for understanding biological processes.

Description: Introduction to the theory and practice of biophysical characterization of macromolecules. The course will be based on primary research literature, although a supporting text will be used for in depth discussion of the methods.

Description: Introduction to techniques of chemical biology including the study of biological macromolecules and their interaction with small molecule ligands and effectors. Explore modern methods for macromolecular isolation, characterization, and for kinetic analysis and modeling.

Description: Introduction to computational chemistry applications including molecular dynamics simulations, density functional theory optimizations, and computational docking of small molecules to protein targets.

Description: CHEM 441/841 and the accompanying lab course, CHEM 443/843, constitute a basic course in inorganic chemistry. Structure, bonding, properties, and reactions of inorganic compounds with emphasis on the relationships and trends that are embodied in the periodic table of the elements.

Description: Introduction to typical inorganic chemistry laboratory techniques through the preparation and characterization of inorganic compounds.

Description: Topics in inorganic chemistry such as bioinorganics, catalysis, organometallic, materials and solid state chemistry. Theoretical principles and practical applications, and on correlating the physical and chemical properties of the chemical elements and inorganic chemical compounds.

Description: Redox (oxidation and reduction)-based biochemical processes (energy generation, oxygen transfer, enzyme catalysis, signaling, gene regulation, and diseases). Recent progress in these areas. Roles of metals in biochemical reactions, metal homeostasis, and biosynthesis of metal cofactors and metal sites. Biochemistry and pathophysiology of redoxactive species and radicals. Antioxidant molecules and enzymes.

Description: Biosynthetic pathways for bioactive natural products and pathway engineering with an emphasis on those that are medicinally significant, including the biosynthesis of fatty acids, polyketides, phenylpropanoids, terpenoids, steroids, alkaloids, non-ribosomal peptides, and carbohydrates.

Description: Survey of modern concepts of structure/bonding, acidity/basicity, stereochemistry, and reaction mechanisms. Introduction to the fundamental tools used to investigate reaction mechanism (transition state theory, elementary Huckel theory, linear free energy relationships, rate laws and kinetic isotope effects). Mechanistic examples emphasize the major classes of organic reactions, particularly concerted, carbanionic and carbocationic. Development of reasoning skills.

Description: Modern reactions and methodology for organic synthesis. Carbon-carbon bond-forming reactions; alkene synthesis; oxidation; reductions; function group interconversion; use of protecting groups; and organometallic reagents.

Description: Additional reactions of importance for organic synthesis. Examples of topics which may be covered include cycloadditions, rearrangements, and radical-based trnasofmations.

Description: Organic reactions of particular relevance to interdisciplinary research in analytical/bioanalytical chemistry, biochemistry, and the life sciences. Formation of esters, thioesters, and amides; surface functionalization of inorganic or polymer supports; methods for cross-linking, conjugation, or immobilization of chemicals and biomolecules.

Description: Conceptual and mathematical foundations of classical and statistical thermodynamics. Applications of thermodynamics to phase and chemical equilibria. Thermodynamics of solutions of small molecules and of polymers. Biological applications of thermodynamics. Introduction to chemical and biochemical spectroscopy.

Description: Topical chemistry content for high school teachers organized according to the National Science Education Standards. A maximum combined total of 12 hours from TEAC *869 and/or *874 may be counted toward a masters degree. Credit in this course will not count towards a graduate degree in chemistry. Courses are Web-based.

Description: Topical chemistry content for high school teachers organized according to the National Science Education Standards. A maximum combined total of 12 hours from TEAC *869 and/or *874 may be counted toward a masters degree. Credit in this course will not count towards a graduate degree in chemistry. Courses are Web-based.

Description: Laboratory-based courses addressing specific issues connected with teaching laboratory work in high school chemistry programs. Credit in this course will not count towards a graduate degree in chemistry.

Description: CHEM 481/881 and 482/882 with accompanying lab 484/884 form a continuous basic course in physical chemistry for students interested in chemistry as a profession. Introduction to quantum mechanics and statistical mechanics; application to problems in atomic and molecular structure and to spectroscopy.

Description: Thermodynamics and statistical mechanics and their application to the study of solids, liquids, gases, solutions, phase equilibria, and chemical equilibria. Chemical kinetics and reaction dynamics.

Description: Applications of physical measurements and principles to study chemical systems and processes.

Description: A one-semester survey course in modern physical chemistry, covering chemical thermodynamics, chemical kinetics, quantum chemistry, molecular structure and spectroscopy.

Description: Applications of thermodynamics to biochemical phenomena, optical properties of proteins and polynucleotides, and kinetics of rapid reactions.

Description: Series of lectures and activities designed to prepare for graduate research and graduate studies in chemistry.

Description: Preparation for and presentation of the Research Update Interview. Open to graduate students in Chemistry in the third semester of their program, or with instructor permission.

Description: Preparation for and presentation of an Original Research Proposal. Open to graduate students in Chemistry in the sixth semester of their program, or with instructor permission.

Description: Advanced theory and techniques of nuclear magnetic resonance (NMR) spectroscopy and its application to the structural and dynamic analysis of macromolecules and macromolecule-ligand complexes.

Description: Protein structure and function.

Description: Kinetics regulation and reaction mechanisms of enzymes.

Description: Detailed examination of dynamic control mechanisms of genome maintenance and gene regulation. Mechanisms of transcription, translation, and replication based on analysis of current and seminal literature.

Description: Current metabolic research at the bioenergetic, metabolomic, and molecular level. The normal metabolic processes that go awry in cancer, obesity, and oxidative stress.

Description: The fundamentals of molecular biology and biotechnology and applications. The fundamentals include methods for DNA cloning, sequencing, annotation, recombination, mutagenesis, and expression. The applications include the production of molecular diagnostics and therapeutic agents etc. with a focus on the molecular biotechnology of microbial systems.

Description: Advanced course dealing with the structure, bonding, properties, and reactions of inorganic solid materials.

Description: Chemistry of the metallic compounds.

Description: The chemistry of compounds that occupy the boundary between inorganic and organic chemistry.

Description: Types of stereoisomerism in organic compounds. Steric strain and certain other steric effects in reactions of organic substances.

Description: Classes of reaction mechanisms and the methods whereby mechanisms may be studied. Kinetic and equilibrium studies; isotopic labeling; activation parameters; linear free energy relationships; stereochemistry; NMR and other spectroscopic methods as applied to reaction mechanisms, including direct observation of reactive intermediates; interpreting the results of semi-empirical calculations of reaction pathways; and studies of acid- and base-catalysis mechanisms.

Description: Elementary aspects of molecular orbital (MO) theory. Selected concepts in molecular symmetry and topology. Applications of MO calculations to reaction mechanisms and elucidation of electronic structure for organic molecules: calculations vs. experiment. Introduction to selected interdisciplinary topics.

Description: Use of organometallic reagents and catalysts in organic synthesis.

Description: Organic chemistry of biological systems with particular emphasis on the molecular mechanisms of action of enzymes and their associated cofactors.

Description: Strategy and execution of organic synthesis. Retrosynthetic analysis; total synthesis of natural and unnatural products; methods for asymmetric synthesis; and applications of pericyclic reactions.

Description: Basic principles of quantum mechanics applied to problems in molecular structure and chemical bonding.

Description: Principles of thermodynamics, with applications to chemical systems and processes, and illustrations from current literature.

Description: Application of equilibrium statistical mechanics to problems of chemical interest. Calculation of thermodynamic functions from molecular structure data. Molecular theories of gases, liquids, and solutions.

Description: Concepts and equations; successive, competing, and reversible reactions; equilibrium, collision, and activated-complex theories; reaction mechanism; heterogeneous reactions; current literature.

Description: A quantitative treatment of the principal methods of electronic, optical, and magnetic resonance spectroscopy.

Description: A quantitative treatment of the principal methods of light, electron and neutron scattering.

Description: CHEM 990 consists of monthly lectures presented by guest speakers from other colleges and universities, the government, and industry. Registration in CHEM 990 is required of all full-time CHEM graduate students. Current topics of chemical interest.

Description: Topics of special interest in modern organic chemistry.

Description: Presentations of current and original Biochemistry research.